The human body would have, just like in animals, a kind of internal balance , or a self-regulating system of weight , so if you tend to get fat, the body receives signals to reduce the sense of hunger and increase the sense of satiety. , thus reducing the intake of food: a homeostasis of body weight, which pushes our body to balance even in weight, as well as in all biological processes that affect us.
A team of Swedish scientistshe would have noticed this mechanism, baptized with the name of gravitostat (homeostasis of body weight) in rodents, and is convinced that the same mechanism also exists in humans. The self-regulating weight signals would act independently of the hunger and satiety hormones, and would be linked to osteocytes (the main cells of bone tissue) located in the femur. These signals would then independently regulate body fat . Okay, you say, but this happens in mice.
And in humans?
The interesting thing that would also explain a connection with humans, therefore the existence also in men and women of a self-regulating weight system,is the correlation between sedentary lifestyle and the risk of metabolic syndrome , highlighted in the past by a series of epidemiological studies. Why does sitting longer increase the risk of gaining weight?
It was once thought that the more time you spent sitting, the fewer calories you burned, but in recent years new studies had already denied that the risk of obesity was related to a lower total energy expenditure. 

Basically: if you are sitting you burn fewer calories than you are standing and we know this.
But it is a few calories of difference , which does not explain why those who are sedentary risk a greater accumulation of body fat, especially abdominal.
And here comes the fun. What if the reason why those who spend too much time sitting tend to accumulate fat, especially visceral fat, were linked to an inhibition of these sensors at the femoral level? When you tend to gain weight, the fact that you spend a lot of time sitting could confuse the communication between the brain and these sensors in the femoral osteocytes. This would also perhaps explain why, in this previous study , there was a correlation between those with thin and lanky legs and the body’s metabolism.. People with less toned and leaner legs would have a slower metabolism (and a higher risk of metabolic syndrome). On the other hand, this internal balance activated by the osteocytes of the femur would regulate insulin sensitivity and glucose tolerance. Therefore, lower risk of metabolic syndrome.
While waiting to understand more, this advice applies: spend more time on your feet. This should reduce the risk of obesity in humans as well.