A low carb high fat diet, such as a ketogenic to the Bulletproof Diet, so to speak, but also the Paleo diet, that is, with few carbohydrates and the highest percentage of fat macronutrients, in an experiment conducted on mice would have worsened the insulin resistance of guinea pigs, and led to an accumulation of fat in the liver and impaired pancreatic activity . A group of mice fed a low carb high fat diet, in fact, would have gained weight in nine weeks of diet, accumulating mainly body fat (white adipocytes), while plasma triglycerides would have been reduced compared to a control group. While blood glucose remained unchanged, experts noted the emergence of insulin resistance after a night of fasting., i.e. an excessive insulin response after a night of fasting following a normal meal, compared to the control group. What does it mean?
Although scientists from the Austin Hospital Department of Medicine and the University of Melbourne, who conducted the study published in the journal Nature , are cautious about comparing a low carb high fat diet in mice with the effects of the same diet in humans , Given the growing popularity of this diet, they wondered if actually doing at least two and a half months of this diet could improve insulin sensitivity, and therefore be a valid response to the growing obesity and diabetes in the Western population.
Their data instead express the opposite: those who follow a low carb high fat diet run the risk of being insulin resistant , also due to an excess of fat that would weigh on the liver, reducing its functionality. Not only that, but eating more fat and fewer carbohydrates would lead in the long run to an increase in body weight, and in particular in fat.