The Food and Drug Administration has given the green light to the marketing of an Orexigen drug, the Contrave pill, in Italian market under the name of Mysimba.

Studies on its effectiveness are promising. Orexygen stated that there is no effect on the cardiovascular system, so Mysimba is a fairly safe weight loss drug.
But it should only be prescribed under certain conditions.

But how does Orexigen Mysimba work?

Approved after a rather troubled history and several rejections by the FDA, the Mysimba diet pill is a compound that combines bupropion and naltrexone , an antidepressant and drug and alcohol addiction medication, respectively. The Mysimba slimming pill makes you lose weight thanks to a “hunger-blocking” effect confirmed by a trial, or by a clinical pharmacological study, started in 2012 on nine thousand patients.
The drug is sold by prescription only.

In which cases it is indicated

Mysimba therefore works by inhibiting appetite, and is prescribed in cases of severe overweight or moderate obesity (30-27 BMI). In addition to this it is only suitable for those who do not have kidney and / or liver diseases and who have at least one of the following problems: type 2 diabetes, high blood pressure, high cholesterol.

Therefore it can be said that the use of Mysimba is indicated in patients suffering from metabolic syndrome. 
See under the heading: metabolic syndrome. 

The drug, available in tablets, is prescribed by the doctor if these conditions occur and always considering that the patient must have indications for following a low-calorie diet and exercising.

According to a study in which patients took Mysimba for a year, the weight loss was 13-14 pounds on average.
All in all, a modest loss, it must be said.
However, the manufacturer claims that the results are subjective.

The doctor is required to stop the drug if in 4 months of taking the patient has not lost at least 5% of his body weight.