The discovery of a vaccine that could correct problems with metabolism, and in particular with metabolic syndrome, comes from Japan, and to be precise from the University of Osaka.

A condition in which we find both an excess of visceral fat and disorders in the level of blood sugar, cholesterol, pressure or high triglycerides. And that often takes over with advancing age. Let’s see the news of the study in detail.

ARRIVES THE VACCINE FOR METABOLISM PROBLEMS

The vaccine has currently only been tested on mice with metabolic syndrome. It therefore takes years for it to be marketed, if it passes the tests on subjects suffering from metabolism problems. Its mechanism of action is curious.

In essence, this vaccine wipes out the old T lymphocytes, cells of the immune system, which “weigh” on the younger lymphocytes creating an inflammatory environment. In fact, old lymphocytes accumulate in body fat over the years. As a result, body fat tends to become inflamed, and over the years those who are overweight begin to have problems with metabolism, in particular with high blood sugar and high cholesterol.
Therefore body fat, as had already been confirmed by various studies, is not an “inert” fat. But it is a fat that signals a degree of inflammation, and therefore causes a situation of metabolic imbalance in particular glycemic. This would explain the correlation between being overweight and type 2 diabetes, which is very common.

HOW THE VACCINE AGAINST METABOLIC SYNDROME WORKS

The vaccine eliminates old T lymphocytes that accumulate in body fat. It distinguishes them from new lymphocytes, which instead do not cause an inflammatory state of adipose tissue, through a surface protein found only on senescent cells, CD153. The disappearance of the old T lymphocytes by the vaccine resolved a condition of diabetes in overweight mice. After the vaccine, the researchers subjected the mice to an oral glucose tolerance test, finding that their sensitivity to glucose, hence their tolerance level, had significantly improved. The results are very encouraging, so much so that researchers believe they have discovered an effective tool to combat metabolic syndrome and type 2 diabetes.